books عائلات المستقبلات النووية

فيما يلي قائمة ب 48 مستقبل نووي بشري معروف حاليا مصنفة حسب تشابه التسلسل.

هذه القائمة منظمة كالتالي:

Subfamily: name

Group: name (endogenous ligand if common to entire group)

Member: name (abbreviation; NRNC Symbol, gene) (endogenous ligand)

Subfamily 1: Thyroid Hormone Receptor-like

• Group A: Thyroid hormone receptor (هرمونات الغدة الدرقية)
  • 1: Thyroid hormone receptor-α (TRα; NR1A1, THRA)
  • 2: Thyroid hormone receptor-β (TRβ; NR1A2, THRB)
• Group B: مستقبل حمض الريتينويك (فيتامين ألف and related compounds)
  • 1: Retinoic acid receptor-α (RARα; NR1B1, RARA)
  • 2: Retinoic acid receptor-β (RARβ; NR1B2, RARB)
  • 3: Retinoic acid receptor-γ (RARγ; NR1B3, RARG)
• Group C: مستقبل مكاثر البيروكسيسوم المنشط
  • 1: Peroxisome proliferator-activated receptor-α (PPARα; NR1C1, PPARA)
  • 2: Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ; NR1C2, PPARD)
  • 3: Peroxisome proliferator-activated receptor-γ (PPARγ; NR1C3, PPARG)
• Group D: Rev-ErbA
  • 1: Rev-ErbAα (Rev-ErbAα; NR1D1)
  • 2: Rev-ErbAβ (Rev-ErbAβ; NR1D2)
• Group F: RAR-related orphan receptor
  • 1: RAR-related orphan receptor-α (RORα; NR1F1, RORA)
  • 2: RAR-related orphan receptor-β (RORβ; NR1F2, RORB)
  • 3: RAR-related orphan receptor-γ (RORγ; NR1F3, RORC)
• Group H: Liver X receptor-like
  • 3: Liver X receptor-α (LXRα; NR1H3)
  • 2: Liver X receptor-β (LXRβ; NR1H2)
  • 4: Farnesoid X receptor (FXR; NR1H4)
• Group I: Vitamin D receptor-like
  • 1: مستقبل كالسيتريول (VDR; NR1I1, VDR) (فيتامين دي)
  • 2: Pregnane X receptor (PXR; NR1I2)
  • 3: Constitutive androstane receptor (CAR; NR1I3)

Subfamily 2: Retinoid X Receptor-like

• Group A: Hepatocyte nuclear factor-4 (HNF4)
  • 1: Hepatocyte nuclear factor-4-α (HNF4α; NR2A1, HNF4A)
  • 2: Hepatocyte nuclear factor-4-γ (HNF4γ; NR2A2, HNF4G)
• Group B: مستقبل ريتينويد أكس (RXRα)
  • 1: Retinoid X receptor-α (RXRα; NR2B1, RXRA)
  • 2: Retinoid X receptor-β (RXRβ; NR2B2, RXRB)
  • 3: Retinoid X receptor-γ (RXRγ; NR2B3, RXRG)
• Group C: Testicular receptor
  • 1: Testicular receptor 2 (TR2; NR2C1)
  • 2: Testicular receptor 4 (TR4; NR2C2)
• Group E: TLX/PNR
  • 1: TLX (TLX; NR2E1)
  • 3: Photoreceptor cell-specific nuclear receptor (PNR; NR2E3)
• Group F: COUP/EAR
  • 1: Chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI; NR2F1)
  • 2: Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; NR2F2)
  • 6: V-erbA-related (EAR-2; NR2F6)

Subfamily 3: Estrogen Receptor-like

See also steroid and sex hormone receptors

• Group A: مستقبلات الاستروجين (هرمون تناسليs: إستروجين)
  • 1: Estrogen receptor-α (ERα; NR3A1, ESR1)
  • 2: Estrogen receptor-β (ERβ; NR3A2, ESR2)
• Group B: Estrogen related receptor
  • 1: Estrogen related receptor-α (ERRα; NR3B1, ESRRA)
  • 2: Estrogen related receptor-β (ERRβ; NR3B2, ESRRB)
  • 3: Estrogen related receptor-γ (ERRγ; NR3B3, ESRRG)
• Group C: 3-Ketosteroid receptors
  • 1: Glucocorticoid receptor (GR; NR3C1) (كورتيزول)
  • 2: Mineralocorticoid receptor (MR; NR3C2) (ألدوستيرون)
  • 3: Progesterone receptor (PR; NR3C3, PGR) (هرمون تناسليs: بروجستيرون)
  • 4: Androgen receptor (AR; NR3C4, AR) (هرمون تناسليs: تستوستيرون)

Subfamily 4: Nerve Growth Factor IB-like

• Group A: NGFIB/NURR1/NOR1
  • 1: Nerve Growth factor IB (NGFIB; NR4A1)
  • 2: Nuclear receptor related 1 (NURR1; NR4A2)
  • 3: Neuron-derived orphan receptor 1 (NOR1; NR4A3)

Subfamily 5: Steroidogenic Factor-like

• Group A: SF1/LRH1
  • 1: Steroidogenic factor 1 (SF1; NR5A1)
  • 2: Liver receptor homolog-1 (LRH-1; NR5A2)

Subfamily 6: Germ Cell Nuclear Factor-like

• Group A: GCNF
  • 1: Germ cell nuclear factor (GCNF; NR6A1)

Subfamily 0: Miscellaneous

• Group B: DAX/SHP
  • 1: NR0B1, Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX-1; NR0B1)
  • 2: Small heterodimer partner (SHP; NR0B2)
• Group C: Nuclear receptors with two DNA binding domains (2DBD-NR) (A novel subfamily)