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جبلة كرية (Info)


جبلة كروية (بالإنجليزية: Spheroplast ) هي خلية أزيل منها غشاء الخلية أو جدارها الخلوي تحت تأثير البنسلين. وتأتي تلك التسمية من أن الميكروب بعد زوال جداره بالإذابة يتكور وتتخذ شكلا كرويا . تكون الجبلة الكروية حساسة للضغط الأسموزي و تنحل إذا وضعت في محلول مركز ، أي أن يكون السائل خارج الخلية أكثر تركيزا من السائل داخل الخلية.

الاستخدامات

اكتشاف مضادات حيوية

بين عامي 1960 - 1990 استخدمت شركة "ميرك" مسح الجبلة الكروية كطريقة لاكتشاف مضادات حيوية يمكنها منع تكون جدار للخلايا . وفي هذه الطريقة ابتكر "أوجين دولاني" جهازا لاختبار نمو بكتيريا تعوم في سوائل ذات تركيزات مختلفة. واختبرت عقارات تمنع تكوّن جدارا للخلايا وكبرت الخلايا وأصبحت في شكل جبلات كروية. أدت الطريقة إلى ابتكار عدة عقارات مثل fosfomycin , و cephamycin C وغيرها .

التقاط رقعي

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    Authors of books

    Mustafa Mahmoud The Words Of God Almighty Ibrahim AlFiqi Muhammad Bin Saleh AlUthaymeen Ibn Qayyim Al-Jawziyya Ahmed Khaled Tawfiq Fahad Amer AlAhmadi Muhammad Metwally AlShaarawi Ali Bin Jaber AlFifi Dale Carnegie Islam Gamal Sayed Qutb Muhammad AlGhazali Omar AlHourani Agatha Christie Muhammad Bin Ismail AlBukhari Abbas AlAkkad Abu Hamid AlGhazali Najib Mahfouz Jalal AlDin AlSuyuti Fyodor Dostoevsky Bin Taymiyyah Ismail Bin Omar Bin Katheer AlQurashi Aldamashqiu Ibrahim Al-Sukran Mustafa AlAdawi More of Authors of books