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الآليات الحيوية الجزيئية (Info)


يملك الميثيلفنيدات القدرة على إحداث الابتهاج نظرًا لتأثيره الديناميكي الدوائي (أي تثبط إعادة قبط الدوبامين) على نظام المكافأة في الدماغ. بالجرعات العلاجية، لا تفعل منشطات اضطراب نقص الانتباه مع فرط النشاط نظام المكافأة في الدماغ بشكل كافٍ، أو سبل المكافأة بشكل خاص، إلى الدرجة اللازمة لإحداث زيادات مستمرة في التعبير الجيني عن بروتين FOSB في العصبونات الشوكية المتوسط نمط D1 للنواة المتكئة. نتيجة لذلك، عندما يُؤخَذ بالجرعات التي يشيع وصفها طبيًا لعلاج اضطراب نقص الانتباه مع فرط النشاط فإنه الميثيلفنيدات لا تملك القدرة على إحداث إدمان. على أي حال، عندما تُستخدَم الميثيلفنيدات بجرعات ترفيهية عالية بشكل كافٍ بطريق إعطاء ذي توافر حيوي (النفخ أو الإعطاء الوريدي)، خصوصًا من أجل استخدام الدواء كمحرض للابتهاج، تتراكم بروتينات FOSB في النواة المتكئة. لذلك، كأي دواء آخر مسبب للإدمان، في النهاية يرفع الاستخدام الترفيهي المنتظم للميثيلفنيدات بجرعات عالية التعبير المورثي عن بروتين FOSB في العصبونات نمط D1 التي تحرض بدورها سلسلة من شلالات الإشارة المتواسطة بالنسخ الجيني التي تحدث الإدمان.

Source: wikipedia.org
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Corporate Governance (between Concept And Mechanisms) - Part One

Corporate Governance (between Concept And Mechanisms) - Part One
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Internationally Prohibited Weapons (rules And Mechanisms)

Internationally Prohibited Weapons (rules And Mechanisms)
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Artificial Intelligence (ai) Between Application And Mechanisms - Part V

Artificial Intelligence (ai) Between Application And Mechanisms - Part V
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A Preliminary Dissertation on the Mechanisms of the Heavens

A Preliminary Dissertation on the Mechanisms of the Heavens
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Ijtihad Mechanisms

 
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Kinematics of Mechanisms from the Time of Watt

Kinematics of Mechanisms from the Time of Watt
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Mechanisms Of Symbolic Discourse

Mechanisms Of Symbolic Discourse
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Mechanisms For Implementing Gradients

Mechanisms For Implementing Gradients

 
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The Comparative Physiology Of Respiratory Mechanisms

The Comparative Physiology Of Respiratory Mechanisms
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Mechanisms Of Experimentation In Theatrical Performance

Mechanisms Of Experimentation In Theatrical Performance
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Mechanisms Of The Investment Economy

Mechanisms Of The Investment Economy
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Mechanisms For The Protection Of Human Rights In Algeria

Mechanisms For The Protection Of Human Rights In Algeria

 
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Planning And Social Policy `concepts - Frameworks And Mechanisms`
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List Of Defense Mechanisms

 
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Good Speaker - Concepts And Mechanisms

Good Speaker - Concepts And Mechanisms
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Narration In The Fruit Of The Caliphs And The Fruit Of The Caliphs “its Mechanisms And Mechanisms”
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Simplify Work Procedures Methods And Mechanisms
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Fruitful Reading Concepts And Mechanisms

 
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Mechanisms Of Narrative Writing By Umberto Eco

 
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Fourth And Fifth Generation Of Wars 'mechanisms Of Confrontation'
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Mechanisms Of Narrative Writing By Umberto Eco

 
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Financial Analysis And Decision-making Mechanisms

Financial Analysis And Decision-making Mechanisms
2594 Hedging Mechanisms In Islamic Financial Operations

2594 Hedging Mechanisms In Islamic Financial Operations

 
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The Strategic Export Of The Iranian Revolution `an Analytical Study Of The Determinants - Components And Mechanisms`

The Strategic Export Of The Iranian Revolution `an Analytical Study Of The Determinants - Components And Mechanisms`
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The Evolution Of The International Criminal Justice System 'foundations And Mechanisms'

The Evolution Of The International Criminal Justice System 'foundations And Mechanisms'
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Dialogue With The West: Its Mechanisms - Goals - And Motives

Dialogue With The West: Its Mechanisms - Goals - And Motives
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Resistant Arab Flags: A Study Of Mechanisms And Methods

Resistant Arab Flags: A Study Of Mechanisms And Methods
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Mechanisms Of Narrative Writing By Umberto Eco

Mechanisms Of Narrative Writing By Umberto Eco
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Mechanisms Of Photography In The Quranic Scene

 
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Poetic Text And Reading Mechanisms - Fawzi Issa

 
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The publisher is the author
Globalization Concept - Mechanisms And Actors

Globalization Concept - Mechanisms And Actors
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Interpretation And Translation: Approaches To Mechanisms Of Understanding And Interpretation

Interpretation And Translation: Approaches To Mechanisms Of Understanding And Interpretation
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Paranormal Dimensions Parapsychological Mechanisms

Paranormal Dimensions Parapsychological Mechanisms
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Human Rights ; Concepts And Mechanisms

Human Rights ; Concepts And Mechanisms
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Mechanisms From The Crane To The Computer

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Mustafa Mahmoud The Words Of God Almighty Ibrahim AlFiqi Muhammad Bin Saleh AlUthaymeen Ibn Qayyim Al-Jawziyya Ahmed Khaled Tawfiq Fahad Amer AlAhmadi Muhammad Metwally AlShaarawi Ali Bin Jaber AlFifi Dale Carnegie Islam Gamal Sayed Qutb Muhammad AlGhazali Omar AlHourani Agatha Christie Muhammad Bin Ismail AlBukhari Abbas AlAkkad Abu Hamid AlGhazali Najib Mahfouz Fyodor Dostoevsky Jalal AlDin AlSuyuti Bin Taymiyyah Ismail Bin Omar Bin Katheer AlQurashi Aldamashqiu Ibrahim Al-Sukran Mustafa AlAdawi More of Authors of books